Retrospective Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2017; 23(3): 505-515
Published online Jan 21, 2017. doi: 10.3748/wjg.v23.i3.505
Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with stage III and IV colorectal cancer
Jae Hyun Kim, Jun Yeop Lee, Hae Koo Kim, Jin Wook Lee, Sung Gyu Jung, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park
Jae Hyun Kim, Jun Yeop Lee, Hae Koo Kim, Jin Wook Lee, Sung Gyu Jung, Kyoungwon Jung, Sung Eun Kim, Won Moon, Moo In Park, Seun Ja Park, Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, Busan 602-702, South Korea
Author contributions: Kim JH and Park SJ designed study; Kim JH wrote the paper; Lee JY, Kim HK, Lee JW, Jung K, Kim SE, Moon W and Park MI critically reviewed the manuscript for important intellectual content; and Park SJ approved the manuscript; all the authors contributed to this manuscript.
Institutional review board statement: This is to certify that the information contained herein is true and correct as reflected in the records of the KUGH lRB. We certify that KUGH IRB is in full complicance with good clinical practice as defined under Ministry of Food and Drug Safety (MFDS) regulations and the International Conference on Harmonization (lCH) guidelines.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Seun Ja Park, MD, Division of Gastroenterology, Department of Internal Medicine, Kosin University College of Medicine, 34 Amnam-dong, Seo-gu, Busan 602-702, South Korea. parksj6406@daum.net
Telephone: +82-51-9905061 Fax: +82-51-9905055
Received: October 25, 2016
Peer-review started: October 26, 2016
First decision: December 1, 2016
Revised: December 5, 2016
Accepted: December 21, 2016
Article in press: December 21, 2016
Published online: January 21, 2017
Core Tip

Core tip: Recently, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been suggested as important inflammatory markers and potential predictors of long-term outcomes in patients with colorectal cancer (CRC). However, the direct impact of NLR and PLR on long-term outcomes in patients with CRC remains inconclusive. In this study, we identified that high NLR and high PLR are useful independent prognostic factors to predict poor long-term outcomes in patients with stage III and IV CRC. And we propose that initial assessment of NLR and PLR in newly diagnosed stage III and IV CRC patients is important for predicting long-term outcomes.