Efficacy of tolvaptan for the patients with advanced hepatocellular carcinoma
Masayuki Miyazaki, Masayoshi Yada, Kosuke Tanaka, Takeshi Senjyu, Kenta Motomura, Akihide Masumoto, Department of Hepatology, Iizuka Hospital, Iizuka 820-8505, Japan
Takeshi Goya, Motoyuki Kohjima, Masaki Kato, Department of Medicine and Bioregulatory Science, Graduate School of Medical Science, Kyushu University, Fukuoka 810-0065, Japan
Kazuhiro Kotoh, Department of Hepatology, Harasanshin Hospital, Fukuoka 812-0033, Japan
Author contributions: Miyazaki M, Motomura K and Kotoh K wrote the paper; Yada M, Tanaka K, Senjyu T and Kotoh K analyzed the data; Kohjima M, Kato M and Masumoto A supervised writing of the paper; all authors contributed to this manuscript.
Institutional review board statement: This study protocol was approved by the Ethics Committees at Iizuka Hospital (approval No. 15174).
Informed consent statement: For this type of retrospective study formal consent in not required. Only patient administered tolvaptan at 15 mg/day received a sufficient explanation of the aim and contents of this study.
Conflict-of-interest statement: The authors declare no conflict of interest in this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Masayuki Miyazaki, MD, Department of Hepatology, Iizuka Hospital, 3-83 Yoshio, Iizuka 820-8505, Japan. firstname.lastname@example.org
Telephone: +81-948-223800 Fax: +81-948-29574
Received: January 19, 2017
Peer-review started: January 19, 2017
First decision: February 23, 2017
Revised: March 10, 2017
Accepted: April 21, 2017
Article in press: April 21, 2017
Published online: August 7, 2017