Basic Study
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2017; 23(29): 5313-5323
Published online Aug 7, 2017. doi: 10.3748/wjg.v23.i29.5313
Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal
Hyun Jung Kim, Guem San Lee, Hyungwoo Kim, Byung Joo Kim
Hyun Jung Kim, Byung Joo Kim, Division of Longevity and Biofunctional Medicine, Healthy Aging Korean Medical Research Center, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea
Guem San Lee, Wonkwang University College of Korean Medicine, Iksan 54538, South Korea
Hyungwoo Kim, Division of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan 50612, South Korea
Byung Joo Kim, Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Gyeongsangnamdo 50612, South Korea
Author contributions: Kim HJ and Kim BJ designed the research; Kim HJ, Lee GS and Kim H performed the experiments; Kim HJ and Kim BJ analyzed the data; and Kim HJ and Kim BJ wrote the paper.
Supported by the National Research Foundation of Korea Grant funded by the Korea Government (MSIP), No. 2014R1A5A2009936.
Institutional animal care and use committee statement: The animal care and experiments in accordance with the guidelines issued by the Institutional Animal Care and Use Committee at Pusan National University (Busan, Republic of Korea; Approval No. PNU-2015-1036).
Conflict-of-interest statement: The authors have no disclosures to report.
Data sharing statement: No additional are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Byung Joo Kim, PhD, Associate Professor, Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Beomeori, Mulgeum-eup, Yangsan, Gyeongsangnamdo 50612, South Korea. vision@pusan.ac.kr
Telephone: +82-51-5108469 Fax: +82-51-5108420
Received: March 2, 2017
Peer-review started: March 4, 2017
First decision: April 6, 2017
Revised: April 18, 2017
Accepted: June 9, 2017
Article in press: June 12, 2017
Published online: August 7, 2017
Core Tip

Core tip: Hwangryunhaedok-tang, a traditional herbal medicine, has been used to treat gastrointestinal diseases. Our data suggest that HHT can depolarize the pacemaker potentials of cultured interstitial cells of Cajal from mouse small intestine and may be a novel prokinetic agent.