Effect of EPEC endotoxin and bifidobacteria on intestinal barrier function through modulation of toll-like receptor 2 and toll-like receptor 4 expression in intestinal epithelial cell-18
Xia Yang, Xian-Chun Gao, Jun Liu, Hong-Yu Ren, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Yang X and Gao XC contributed equally as co-first authors; Ren HY conceived and designed the experiments; Yang X and Gao XC performed the majority of experiments, analyzed the data and wrote the paper; Ren HY and Liu J provided reagents, materials and analytical tools; all authors read and approved the final manuscript.
Supported by Medjaden Academy and Research Foundation for Young Scientists, No. MJA20170410.
Institutional review board statement: This study was approved by the Institutional Review Board of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.
Conflict-of-interest statement: None of the authors have any potential conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hong-Yu Ren, MD, PhD, Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan 430022, Hubei Province, China. email@example.com
Received: February 10, 2017
Peer-review started: February 11, 2017
First decision: March 16, 2017
Revised: April 23, 2017
Accepted: May 19, 2017
Article in press: May 19, 2017
Published online: July 14, 2017