Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2017; 23(2): 336-344
Published online Jan 14, 2017. doi: 10.3748/wjg.v23.i2.336
Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis
Amélie Cayzeele-Decherf, Fanny Pélerin, Sébastien Leuillet, Benoit Douillard, Béatrice Housez, Murielle Cazaubiel, Gunnard K Jacobson, Peter Jüsten, Pierre Desreumaux
Amélie Cayzeele-Decherf, Fanny Pélerin, Peter Jüsten, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France
Sébastien Leuillet, Benoit Douillard, Béatrice Housez, Murielle Cazaubiel, Biofortis - Mérieux NutriSciences, 44800 Saint Herblain, France
Gunnard K Jacobson, Lesaffre Yeast Corporation, Lesaffre Group, Milwaukee, WI 53214, United States
Pierre Desreumaux, CHU Lille, Department of Gastroenterology, Claude Huriez Hospital, 59000 Lille, France
Pierre Desreumaux, Lille University North of France, 59000 Lille, France
Pierre Desreumaux, INSERM U995, 59000 Lille, France
Author contributions: All authors have made substantial contributions to conception and design of the study, acquisition of data, analysis and interpretation of data; Cayzeele-Decherf A, Leuillet S and Housez B have drafted the article and other authors have made critical revisions related to important intellectual content of the manuscript; All authors have been involved for final approval of the version of the article to be published.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Amélie Cayzeele-Decherf, Clinical Study Manager, Lesaffre Human Care, Lesaffre Group, 59700 Marcq en Baroeul, France.
Telephone: +33-3-20148320
Received: August 2, 2016
Peer-review started: August 3, 2016
First decision: September 12, 2016
Revised: October 3, 2016
Accepted: October 19, 2016
Article in press: October 19, 2016
Published online: January 14, 2017
Core Tip

Core tip: Since the gut microbiota is considered to play a role in the pathophysiology of Irritable Bowel Syndrome, the use of probiotics has gained interest for the management of gastrointestinal symptoms of irritable bowel syndrome (IBS). However, the properties of probiotics are strain-dependent. We performed an individual patient data meta-analysis to assess the effectiveness of Saccharomyces cerevisiae CNCM I-3856 on the management of IBS symptoms.