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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 14, 2017; 23(18): 3322-3329
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3322
Published online May 14, 2017. doi: 10.3748/wjg.v23.i18.3322
Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis
Basavaraj Kerur, Pediatric Gastroenterology, Hasbro Children’s Hospital, Providence, RI 02903, United States
Heather J Litman, Corrona, LLC Southborough, MA 01772, United States
Julia Bender Stern, Sarah Weber, Paul A Rufo, Athos Bousvaros, Inflammatory Bowel Disease Center, Children’s Hospital Boston, MA 02115, United States
Jenifer R Lightdale, Division of Pediatric Gastroenterology, UMass Memorial Medical Center, University Campus Worcester, MA 01655, United States
Author contributions: Kerur B designed the study, extracted clinical information, manuscript writing; Litman HJ statistical analysis; Stern JB data collection/chart review/SPSS database maintenance; Weber S data collection/chart review/SPSS database maintenance; Lightdale JR review of endoscopic disease activity; Rufo PA review of endoscopic disease activityAnalysis of endoscopic score; Bousvaros A designed the study, reviewed charts and endoscopic disease activity, manuscript writing, project supervisor.
Institutional review board statement: Approved by IRB Boston Childrens Hospital.
Informed consent statement: Retrospective review of clinical charts, waiver of consent was obtained from IRB.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Basavaraj Kerur, MD, Pediatric Gastroenterology, Hasbro Children’s Hospital, Providence, MPH 134, 593 Eddy St, RI 02903, United States. kerurbas@gmail.com
Telephone: +1-401-4448306 Fax: +1-401-4448748
Received: October 26, 2016
Peer-review started: October 28, 2016
First decision: December 19, 2016
Revised: January 10, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: May 14, 2017
Peer-review started: October 28, 2016
First decision: December 19, 2016
Revised: January 10, 2017
Accepted: April 12, 2017
Article in press: April 12, 2017
Published online: May 14, 2017
Core Tip
Core tip: There is controversy regarding what the best method of assessing disease activity in pediatric ulcerative colitis. Currently, the best accepted tool is the pediatric ulcerative colitis activity index (PUCAI), developed by Turner and colleagues, which is a physician reported measure. Because of its formal validation and ease of use, the PUCAI has been widely accepted both as a clinical tool by physicians. Other experts have suggested that biomarkers, patient reported outcomes, or endoscopic disease activity may be better measures. In this study, we show physicians looking at endoscopic photos may grade the Mayo endoscopic scores differently, and that the PUCAI generally correlates well with endoscopic disease activity.