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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 14, 2017; 23(14): 2585-2591
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2585
Published online Apr 14, 2017. doi: 10.3748/wjg.v23.i14.2585
PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma
Shi-Yuan Liu, Zhe Qiao, Jian-Tao Jiang, Shao-Min Li, Wei Zhang, Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Wei Chen, Department of Medical Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, Gansu Province, China
Ehtesham Annait Chughtai, Xi’an Jiaotong University School of Medicine, Xi’an 710061, Shaanxi Province, China
Author contributions: Liu SY, Chen W and Zhang J designed the research; Qiao Z, Jiang JT, Li SM and Zhang W performed the research; Liu SY and Chughtai EA analyzed data; Liu SY and Chughtai EA wrote the paper.
Supported by National Natural Science Foundation of China , No. 81602023 .
Institutional review board statement: Written consent was obtained from each subject and the study procedures were approved by the ethical committees of the Second Affiliated Hospital of Xi’an Jiaotong University.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Jin Zhang, Department of Thoracic Surgery, Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xi Wu Lu, Xi’an 710004, Shaanxi Province, China. mansteinxjtu@163.com
Telephone: +86-29-87679325
Received: December 30, 2016
Peer-review started: January 1, 2017
First decision: February 9, 2017
Revised: February 19, 2017
Accepted: March 2, 2017
Article in press: March 2, 2017
Published online: April 14, 2017
Peer-review started: January 1, 2017
First decision: February 9, 2017
Revised: February 19, 2017
Accepted: March 2, 2017
Article in press: March 2, 2017
Published online: April 14, 2017
Core Tip
Core tip:PIK3CA gene mutations have been associated with various prognoses in patients with different cancers. However, no large-scale study has examined the prognostic impact of PIK3CA gene mutations in Northwest Chinese esophageal squamous cell carcinoma (ESCC). In this study, we quantified PIK3CA gene mutations via pyrosequencing technology using a non-biased database of 210 curatively resected ESCCs. It was found that PIK3CA gene mutations in Northwest Chinese ESCC are associated with favorable prognoses. It has been suggested that PIK3CA gene mutational status can have a potential role as a prognostic biomarker for ESCC.