Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2016; 22(9): 2749-2759
Published online Mar 7, 2016. doi: 10.3748/wjg.v22.i9.2749
Impact of non-oncological factors on tumor recurrence after liver transplantation in hepatocellular carcinoma patients
Xiang-Qian Gu, Wei-Ping Zheng, Da-Hong Teng, Ji-San Sun, Hong Zheng
Xiang-Qian Gu, Organ Transplant Center, The First Central Clinical College, Tianjin Medical University, Tianjin 300192, China
Wei-Ping Zheng, Da-Hong Teng, Ji-San Sun, Hong Zheng, Organ Transplant Center, Tianjin First Central Hospital, Tianjin 300192, China
Author contributions: Zheng H performed the review; Gu XQ wrote the paper; Zheng WP, Teng DH and Sun JS revised the review.
Supported by National High-Tech R and D Program (863 Program; No. 2012AA021003); and the Tianjin Municipal Health Bureau Key Project, No. 13KG103.
Conflict-of-interest statement: The authors declare no conflicts of interests for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Hong Zheng, PhD, MD, Professor, Organ Transplant Center, Tianjin First Central Hospital, 24 Fukang Road, Nankai District, Tianjin 300192, China.
Telephone: +86-22-23626112 Fax: +86-22-23626112
Received: October 28, 2015
Peer-review started: October 28, 2015
First decision: November 27, 2015
Revised: December 13, 2015
Accepted: December 30, 2015
Article in press: December 30, 2015
Published online: March 7, 2016
Core Tip

Core tip: Liver transplantation (LT) has become one of the best curative therapeutic options for patients with hepatocellular carcinoma (HCC). This review discusses the effects of non-oncological factors on tumor recurrence after LT in patients with HCC. These non-oncological factors include the use of immunosuppressive agents, transplant type, hepatitis virus infection, recipient characteristics, and graft-related factors. Our review provides new research ideas and clinical strategies for the prophylaxis and surveillance of post-LT tumor recurrence, and can help the reader improve their management of, and outcomes among, patients with HCC after LT.