Published online Feb 14, 2016. doi: 10.3748/wjg.v22.i6.1935
Peer-review started: July 8, 2015
First decision: September 29, 2015
Revised: December 9, 2015
Accepted: December 30, 2015
Article in press: December 30, 2015
Published online: February 14, 2016
Core tip: A combination of imaging-guided local percutaneous and transarterial treatments of hepatocellular carcinoma is a promising strategy for tumors exceeding 3 cm in diameter and for multifocal tumors that are not amenable to resective surgery and for which the use of a single locoregional treatment option is often inadequate. In this paper, we assessed the indications, the technical aspects, the clinical efficacy and the safety of the different strategies of combining local non-surgical treatments for hepatocellular carcinoma complicating liver cirrhosis. The aim of this review is to explain the technical aspects of different combined treatments and to analyze and comprehensively compare the clinical efficacy and safety of the combined treatment and monotherapy, either chemoembolization or RF ablation alone, in order to provide clinicians with an unbiased opinion and valuable information.