Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2016; 22(45): 10024-10037
Published online Dec 7, 2016. doi: 10.3748/wjg.v22.i45.10024
Preoperative evaluation of pancreatic ductal adenocarcinoma with synchronous liver metastasis: Diagnosis and assessment of unresectability
Hao-Jun Shi, Chen Jin, De-Liang Fu
Hao-Jun Shi, Chen Jin, De-Liang Fu, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, Shanghai 200040, China
Author contributions: Shi HJ contributed to the conception and design of the study, data acquisition, analysis and interpretation, drafting and revising the article, and final approval of the version to be published; Jin C and Fu DL contributed to the conception and design of the study and final approval of the article.
Supported by the National Natural Science Foundation of China, No. 81472221; Clinical key projects of the National Health and Family Planning-Oncology 2013-2015.
Institutional review board statement: The study was reviewed and approved by the Fudan University Huashan Hospital Ethical Committee and Institutional Review Board.
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: De-Liang Fu, MD, PhD, Professor, Department of Pancreatic Surgery, Pancreatic Disease Institute, Huashan Hospital, Fudan University, 12 Urumchi Middle Road, Shanghai 200040, China. surgeonfu@163.com
Telephone: +86-21-52887164 Fax: +86-21-52888277
Received: August 4, 2016
Peer-review started: August 5, 2016
First decision: September 5, 2016
Revised: September 9, 2016
Accepted: October 19, 2016
Article in press: October 19, 2016
Published online: December 7, 2016
Core Tip

Core tip: The presence of liver metastasis from pancreatic ductal adenocarcinoma (PDAC) usually deprives patients of opportunities for resection of PDAC. We utilized a series of clinical parameters for pre-operative evaluation of PDAC with synchronous liver metastasis, including diagnosis and assessment of unresectability. The criterion set up by serum CA125 levels could facilitate the careful judgement of the occurrence of synchronous liver metastases from PDAC, and the prudent selection of appropriate patients for simultaneous resections for primary PDAC and synchronous liver metastasis, for the sake of prolonged survival and substantial reduction in morbidity and mortality.