Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 7, 2016; 22(45): 10009-10014
Published online Dec 7, 2016. doi: 10.3748/wjg.v22.i45.10009
Heparin bridge therapy and post-polypectomy bleeding
Toshiyuki Kubo, Kentaro Yamashita, Kei Onodera, Tomoya Iida, Yoshiaki Arimura, Masanori Nojima, Hiroshi Nakase
Toshiyuki Kubo, Kentaro Yamashita, Kei Onodera, Tomoya Iida, Hiroshi Nakase, Department of Gastroenterology and Hepatology, Sapporo Medical University, Sapporo 0608543, Japan
Yoshiaki Arimura, Department of Gastroenterology, Otaru City General Hospital, Otaru 0478550, Japan
Masanori Nojima, Center for Translational Research, the Institute of Medical Science, the University of Tokyo, Tokyo 1088639, Japan
Author contributions: Kubo T designed the study and collected and analyzed the data; Kubo T and Yamashita K wrote the manuscript; Onodera K and Iida T provided analytical oversight; Arimura Y supervised the study; Nojima M conducted statistical analysis; Nakase H revised the manuscript for important intellectual content; all authors read and approved the final version.
Institutional review board statement: The Institutional Review Board of Sapporo Medical University approved this study.
Informed consent statement: All participants in this study provided their verbal informed consent prior to study enrollment.
Conflict-of-interest statement: The authors disclose no conflicts of interest.
Data sharing statement: The technical appendix, statistical code and dataset are available from the corresponding author at kubo-t@grape.plala.or.jp Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Toshiyuki Kubo, MD, Department of Gastroenterology and Hepatology, Sapporo Medical University, S1W16 Chuo-ku, Sapporo 0608543, Japan. kubo-t@grape.plala.or.jp
Telephone: +81-11-6112111 Fax: +81-11-6112282
Received: August 29, 2016
Peer-review started: August 31, 2016
First decision: September 21, 2016
Revised: October 7, 2016
Accepted: November 15, 2016
Article in press: November 16, 2016
Published online: December 7, 2016
Core Tip

Core tip: Post-polypectomy bleeding (PPB) is the most common complication of colon polypectomy. In this study, we demonstrated that patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients who take anticoagulants.