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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 28, 2016; 22(44): 9784-9793
Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9784
Published online Nov 28, 2016. doi: 10.3748/wjg.v22.i44.9784
Effects of ω-3 fatty acids on toll-like receptor 4 and nuclear factor-κB p56 in lungs of rats with severe acute pancreatitis
Bin Wang, Xiao-Wei Wu, Mei-Xia Guo, Min-Li Li, Xiao-Bing Xu, Xin-Xin Jin, Xiao-Hua Zhang, Department of Gastroenterology, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
Author contributions: Wang B designed and performed the research and wrote the paper; Wu XW, Xu XB and Jin XX performed the research; Guo MX and Li ML provided analytic tools; Zhang XH designed the paper.
Supported by Jinling Hospital Research Fund , No. 2013064 .
Institutional review board statement: This study has been approved by the Institutional Review Board of Jinling Hospital, Nanjing, China.
Institutional animal care and use committee statement: The study was approved by the Institutional Animal Care and Use Committee of Jinling Hospital. All operations were performed according to international guidelines concerning the care and treatment of experimental animals.
Conflict-of-interest statement: The authors declare that there is no conflict of interest related to this study.
Data sharing statement: No additional unpublished data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Xiao-Hua Zhang, Department of Gastroenterology, Jinling Hospital, 305 Zhong Shan Dong Lu, Nanjing 210002, Jiangsu Province, China. wangbin198528@163.com
Telephone: +86-25-80860027 Fax: +86-25-80860127
Received: July 1, 2016
Peer-review started: July 4, 2016
First decision: August 29, 2016
Revised: September 13, 2016
Accepted: October 10, 2016
Article in press: October 10, 2016
Published online: November 28, 2016
Peer-review started: July 4, 2016
First decision: August 29, 2016
Revised: September 13, 2016
Accepted: October 10, 2016
Article in press: October 10, 2016
Published online: November 28, 2016
Core Tip
Core tip: There is no report about the correlation between ω-3 fatty acids and toll-like receptor 4 (TLR4) expression in lungs of animals with severe acute pancreatitis (SAP). In this study, we investigated the effects of ω-3 fatty acids (ω-3FA) on TLR4 and nuclear factor κB p56 (NF-κBp56) in lungs of rats with SAP and the levels of cytokines in serum to examine the effects of ω-3FA on TLR4 and NF-κBp56 of lungs in rats with SAP.