Published online Jan 28, 2016. doi: 10.3748/wjg.v22.i4.1650
Peer-review started: July 31, 2015
First decision: August 31, 2015
Revised: September 20, 2015
Accepted: November 24, 2015
Article in press: November 24, 2015
Published online: January 28, 2016
Core tip: Direct acting antiviral (DAA) therapy has the potential to eliminate hepatitis C virus (HCV) from the population of organ transplant candidates and recipients and thereby the negative impact of HCV on outcomes. Among non-hepatic organ transplant patients, the biggest barriers currently are limited safety and efficacy data in this population, particularly in those with advanced renal disease, and global variability of access and reimbursement for DAAs. Future research is needed to better assess safety, efficacy and impact of DAA therapy in non-hepatic solid organ transplant, as well as to explore the safety of using HCV infected donors, with prophylactic therapy, to expand the donor pool.