Review
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Oct 21, 2016; 22(39): 8698-8719
Published online Oct 21, 2016. doi: 10.3748/wjg.v22.i39.8698
Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome
Lukasz Kaska, Tomasz Sledzinski, Agnieszka Chomiczewska, Agnieszka Dettlaff-Pokora, Julian Swierczynski
Lukasz Kaska, General, Endocrine and Transplant Surgery, Medical University of Gdańsk, 80-214 Gdańsk, Poland
Tomasz Sledzinski, Agnieszka Chomiczewska, Department of Pharmaceutical Biochemistry, Medical University of Gdańsk, 80-211 Gdańsk, Poland
Agnieszka Dettlaff-Pokora, Julian Swierczynski, Department of Biochemistry, Medical University of Gdańsk, 80-211 Gdańsk, Poland
Julian Swierczynski, State School of Higher Vocational Education in Koszalin, 75-582 Koszalin, Poland
Author contributions: Kaska L, Sledzinski T and Chomiczewska A contributed to the background research, the formulation of the manuscript, and the revision of the manuscript; Dettlaff-Pokora A contributed to background research, formulation of the manuscript, and management of the images; Swierczynski J contributed to background research, formulation of the manuscript, revision of the manuscript, and final approval of the manuscript.
Supported by the Medical University of Gdańsk, No. ST-41 and No. ST-40; the Ministry of Science and Higher Education of the Republic of Poland under the Leading National Research Centre (KNOW) program, No. 2012-2017.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Julian Swierczynski, Professor, Department of Biochemistry, Medical University of Gdańsk, ul. Dębinki 1, 80-211 Gdańsk, Poland. juls@gumed.edu.pl
Telephone: +48-58-34914 62 Fax: +48-58-34914 65
Received: July 12, 2016
Peer-review started: July 14, 2016
First decision: August 8, 2016
Revised: August 23, 2016
Accepted: September 14, 2016
Article in press: September 14, 2016
Published online: October 21, 2016
Core Tip

Core tip: Emerging evidence suggests that increased concentrations of circulating bile acids could, through their interaction with membrane (TGR-5) and nuclear (FXR) receptors, significantly contribute to improved glucose metabolism following bariatric surgery. This review presents information on the potential mechanism of bile acids on the remission of type-2 diabetes following bariatric surgery.