Published online Oct 14, 2016. doi: 10.3748/wjg.v22.i38.8638
Peer-review started: July 13, 2016
First decision: August 19, 2016
Revised: August 27, 2016
Accepted: September 12, 2016
Article in press: September 12, 2016
Published online: October 14, 2016
Core tip: Concomitant therapy is one of the most effective first line regimen for Helicobacter pylori eradication. The comparison with other regimens (sequential or triple) in a selected geographical region (China in this case) implies several issues. The low number of included studies, the lack of quality evaluation and the high heterogeneity may undermine the strength of a meta-analysis. Therefore, further studies are needed to prove which is the best first line eradication treatment in China, according to the geographical differences in antibiotic resistances.