Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2016; 22(35): 8041-8049
Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.8041
Different pre-S deletion patterns and their association with hepatitis B virus genotypes
Bing-Fang Chen
Bing-Fang Chen, School of Medicine, Fu Jen Catholic University, New Taipei City 24205, Taiwan
Author contributions: Chen BF designed and performed the research, analyzed the data, and wrote the paper.
Supported by the National Science Council, Taiwan, No. NSC 96-2320-B-030-004-MY3.
Institutional review board statement: This study was approved by the Institutional Review Board of the National Taiwan University Hospital and Fu Jen Catholic University, Taiwan.
Conflict-of-interest statement: The author declares no conflict of interest.
Data sharing statement: Additional data are available in a supplementary file.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Bing-Fang Chen, PhD, Professor of School of Medicine, Fu Jen Catholic University, 510 Chung-Cheng Road, Hsin-Chuang Dist, New Taipei City 24205, Taiwan. nurs1018@mail.fju.edu.tw
Telephone: + 886-2-29053428 Fax: +886-2-29052096
Received: June 9, 2016
Peer-review started: June 14, 2016
First decision: July 12, 2016
Revised: July 24, 2016
Accepted: August 8, 2016
Article in press: August 8, 2016
Published online: September 21, 2016
Core Tip

Core tip: This is a comprehensive study of the influence of HBV genotypes B (HBV/B) and C (HBV/C) on the emergence of different types of pre-S deletions. Different patterns of pre-S deletion were found in HBV/B and HBV/C. Deletion in the pS2-B1 epitope, nucleocapsid binding site, start codon of M, and site for viral secretion was frequently found in HBV/B. Conversely, deletion in pS2-T and the start codon of L was frequently found in HBV/C. The prevalence of different pre-S deletions differed between HBV/B and HBV/C among patients with liver disease.