Khuroo MS, Rather AA, Khuroo NS, Khuroo MS. Portal biliopathy. World J Gastroenterol 2016; 22(35): 7973-7982 [PMID: 27672292 DOI: 10.3748/wjg.v22.i35.7973]
Corresponding Author of This Article
Mohammad S Khuroo, Director, Digestive Diseases Centre, Dr. Khuroo’s Medical Clinic, Sector 1, SK Colony, Qamarwari, Srinagar, Kashmir 190010, India. khuroo@yahoo.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 21, 2016; 22(35): 7973-7982 Published online Sep 21, 2016. doi: 10.3748/wjg.v22.i35.7973
Portal biliopathy
Mohammad S Khuroo, Ajaz A Rather, Naira S Khuroo, Mehnaaz S Khuroo
Mohammad S Khuroo, Sher-I-Kashmir Institute of Medical Sciences, Srinagar Kashmir 190010, India
Mohammad S Khuroo, Digestive Diseases Centre, Dr. Khuroo’s medical Clinic, Srinagar, Kashmir 190010, India
Ajaz A Rather, Department of Surgery, SKIMS Medical College and Hospital, Bemina, Srinagar, Kashmir 190010, India
Naira S Khuroo, Consultant Radiology, Digestive Diseases Centre, Dr. Khuroo’s Medical Clinic, Srinagar, Kashmir 190010, India
Mehnaaz S Khuroo, Department of Pathology, Govt. Medical College, Srinagar, Kashmir 190001, India
Author contributions: All authors contributed equally; Rather AA, Khuroo NS and Khuroo MS made literature search; Khuroo NS conducted the radiological studies and critically reviewed the images; Khuroo MS and Khuroo NS wrote the paper; all authors read the paper and made necessary corrections.
Supported byDr. Khuroo’s Medical Trust, a nonprofit organization which supports academic activities, disseminates medical education and helps poor patients for medical treatment.
Conflict-of-interest statement: The authors report no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mohammad S Khuroo, Director, Digestive Diseases Centre, Dr. Khuroo’s Medical Clinic, Sector 1, SK Colony, Qamarwari, Srinagar, Kashmir 190010, India. khuroo@yahoo.com
Telephone: +91-194-2492398 Fax: +91-194-2491190
Received: March 28, 2016 Peer-review started: March 29, 2016 First decision: May 12, 2016 Revised: June 22, 2016 Accepted: August 1, 2016 Article in press: August 1, 2016 Published online: September 21, 2016
Core Tip
Core tip: Extrahepatic portal vein obstruction is often encountered in children in India. It is caused by long standing thrombosis of portal vein and leads to cavernous transformation of the bridging venous collaterals. Cholangiographic abnormalities occur in majority of such patients, however, the entity stays asymptomatic in early stages. Biliopathy is a progressive disease and patients surviving to adulthood develop more severe biliary abnormalities and present with clinical disease. Now, portal biliopathy is an important clinical entity faced by hepatologists in India. Since the disease was described in early 90’s, there have been important developments in definition, pathogenesis, diagnostic modalities and therapeutic interventions of portal biliopathy.
