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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 7, 2016; 22(33): 7579-7586
Published online Sep 7, 2016. doi: 10.3748/wjg.v22.i33.7579
Published online Sep 7, 2016. doi: 10.3748/wjg.v22.i33.7579
Clinical characteristics of drug-induced liver injury and primary biliary cirrhosis
Jun Yang, Ya-Li Yu, Yu Jin, Ying Zhang, Chang-Qing Zheng, Division II, Department of Gastroenterology, Shengjing Hospital, China Medical University, Shenyang 110024, Liaoning Province, China
Author contributions: Zheng CQ designed the research; Yang J, Yu YL, Jin Y and Zhang Y performed the research; Yu YL and Zhang Y provided new agents and analytic tools; and Yang J wrote the paper.
Institutional review board statement: This study is a retrospective study of the clinical data of patients. The content of the study is not related to the ethical issues.
Informed consent statement: The authors of this paper guarantee that all study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: There are no conflicts of interest in relation to this manuscript.
Data sharing statement: There are no additional data available in relation to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Chang-Qing Zheng, Professor, Division II, Department of Gastroenterology, Shengjing Hospital, China Medical University, No. 39 Huangxiang Road, Tiexi District, Shenyang 110024, Liaoning Province, China. zhengchangqing88@163.com
Telephone: +86-24-9661526211 Fax: +86-24-9661510351
Received: April 5, 2016
Peer-review started: April 6, 2016
First decision: May 12, 2016
Revised: June 20, 2016
Accepted: July 6, 2016
Article in press: July 6, 2016
Published online: September 7, 2016
Peer-review started: April 6, 2016
First decision: May 12, 2016
Revised: June 20, 2016
Accepted: July 6, 2016
Article in press: July 6, 2016
Published online: September 7, 2016
Core Tip
Core tip: This is a retrospective study to distinguish differential diagnosis of drug-induced liver injury (DILI) and primary biliary cirrhosis (PBC). There are many similarities between the clinical manifestations and biochemical tests of the two diseases. DILI and PBC also show some distinct characteristics, which are helpful to the differential diagnosis of the two diseases.