Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 21, 2016; 22(31): 7111-7123
Published online Aug 21, 2016. doi: 10.3748/wjg.v22.i31.7111
Comparative effects of α2δ-1 ligands in mouse models of colonic hypersensitivity
Mathieu Meleine, Ludivine Boudieu, Agathe Gelot, Emilie Muller, Amandine Lashermes, Julien Matricon, Celine Silberberg, Vassilia Theodorou, Alain Eschalier, Denis Ardid, Frederic A Carvalho
Mathieu Meleine, Ludivine Boudieu, Agathe Gelot, Emilie Muller, Amandine Lashermes, Julien Matricon, Celine Silberberg, Alain Eschalier, Denis Ardid, Frederic A Carvalho, Clermont Université, Université d'Auvergne, INSERM 1107 Neuro-Dol, F-63000 Clermont-Ferrand, France
Mathieu Meleine, Ludivine Boudieu, Agathe Gelot, Emilie Muller, Amandine Lashermes, Julien Matricon, Celine Silberberg, Alain Eschalier, Denis Ardid, Frederic A Carvalho, Université d’Auvergne, INSERM 1107 Neuro-Dol, F-63001 Clermont-Ferrand, France
Vassilia Theodorou, INRA, EI-Purpan, UMR 1054 Neuro-Gastroenterology and Nutrition, F-31000 Toulouse, France
Author contributions: Meleine M and Boudieu L contributed equally to this work; Meleine M, Boudieu L, Gelot A, Muller E, Ardid D and Carvalho FA designed the research; Meleine M, Boudieu L, Muller E and Lashermes A performed the research; Matricon J, Silberberg C, Theodorou V and Eschalier A contributed new analytic tools; Meleine M, Boudieu L, Gelot A, Muller E, Ardid D and Carvalho FA analyzed the data; Meleine M, Boudieu L, Ardid D and Carvalho FA wrote the paper.
Supported by ANR VISCERALGY.
Institutional review board statement: The study was reviewed and approved by the Auvergne University Institutional review board.
Institutional animal care and use committee statement: All animal experiments were performed following the ethical guidelines set out by the International Association for the Study of Pain (IASP), with EU guidelines and the regulations of the French Agriculture and Forestry Ministry (decree 874848) and with approval from local ethical committee (N° CE08-10 and N° CE09-10).
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: There are no additional data available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Frederic A Carvalho, PhD, Université d’Auvergne, INSERM 1107 Neuro-Dol, 28 Place Henri Dunant, BP 38, F-63001 Clermont-Ferrand, France. frederic.carvalho@inserm.fr
Telephone: +33-473-178103 Fax: +33-473-274621
Received: April 19, 2016
Peer-review started: April 21, 2016
First decision: May 27, 2016
Revised: June 9, 2016
Accepted: July 6, 2016
Article in press: July 6, 2016
Published online: August 21, 2016
Core Tip

Core tip: Chronic abdominal pain is commonly reported by patients suffering from gastrointestinal disorders. These patients form a very heterogeneous group in regards to their colonic inflammation status. Such heterogeneity may explain the current lack of satisfactory options regarding pain management in these patients. This preclinical study shows that α2δ-1 ligands are effective against colonic hypersensitivity, especially when they are used in the case of moderate intestinal inflammation. Thus, our results pointed out the need for assessing the clinical benefits of α2δ-1 ligands on chronic abdominal pain based on the level of intestinal inflammation observed in patients.