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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2016; 22(26): 6065-6075
Published online Jul 14, 2016. doi: 10.3748/wjg.v22.i26.6065
Published online Jul 14, 2016. doi: 10.3748/wjg.v22.i26.6065
Impact of biliary stent-related events in patients diagnosed with advanced pancreatobiliary tumours receiving palliative chemotherapy
Angela Lamarca, Christina Rigby, Mairéad G McNamara, Richard A Hubner, Juan W Valle, Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester M20 4BX, Manchester, United Kingdom
Mairéad G McNamara, Juan W Valle, Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester M20 4BX, Manchester, United Kingdom
Author contributions: Lamarca A and Valle JW designed the research; Lamarca A and Rigby C collected the data; Lamarca A performed data analysis; Lamarca A, Rigby C, McNamara MG, Hubner RA and Valle JW were involved in result interpretation and approved the final version of this manuscript.
Supported by Pancreatic Cancer Research Fund and Spanish society of Medical Oncology (Lamarca A).
Institutional review board statement: The study was reviewed and approved by The Christie NHS Foundation Trust (Manchester, United Kingdom); institutional approval number CE15/1400.
Informed consent statement: Not applicable to this study.
Conflict-of-interest statement: Authors declare no conflict-of-interest related to this manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Juan W Valle, Professor, Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester M20 4BX, Manchester, United Kingdom. juan.valle@manchester.ac.uk
Telephone: +44-161-4468106 Fax: +44-161-4463468
Received: December 24, 2015
Peer-review started: December 24, 2015
First decision: January 28, 2016
Revised: February 2, 2016
Accepted: March 1, 2016
Article in press: March 2, 2016
Published online: July 14, 2016
Peer-review started: December 24, 2015
First decision: January 28, 2016
Revised: February 2, 2016
Accepted: March 1, 2016
Article in press: March 2, 2016
Published online: July 14, 2016
Core Tip
Core tip: Most patients diagnosed with advanced malignancies of the pancreas or bile ducts present with biliary obstruction; this requires biliary stenting before starting treatment with palliative chemotherapy. The impact of developing stent-related events (SRE) such as cholangitis or stent obstruction (and the potential role of prophylactic treatment in order to reduce the risk of developing SREs) has not been explored in this patient population. Our results have identified that SREs are common and adversely impact on patient’s morbidity (and possibly mortality) and support the need for prospective studies investigating the role of prophylaxis in this population.