Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2016; 22(24): 5505-5511
Published online Jun 28, 2016. doi: 10.3748/wjg.v22.i24.5505
Published online Jun 28, 2016. doi: 10.3748/wjg.v22.i24.5505
Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update
Franco Scaldaferri, Viviana Gerardi, Francesca Mangiola, Loris Riccardo Lopetuso, Marco Pizzoferrato, Valentina Petito, Alfredo Papa, Giovanni Cammarota, Antonio Gasbarrini, Polo Apparato digerente e sistema Endocrino Metabolico, Gastroenterology Division, Catholic University of Sacred Hearth, 00168 Rome, Italy
Jovana Stojanovic, Andrea Poscia, Institute of Hygiene, Catholic University of Sacred Hearth, 00168 Rome, Italy
Author contributions: Scaldaferri F and Gerardi V equally contributed; Scaldaferri F, Gerardi V and Gasbarrini A contributed to study design; Scaldaferri F, Gerardi V, Mangiola F, Lopetuso LR, Pizzoferrato M, Petito V, Stojanovic J and Poscia A made literature search; Scaldaferri F and Gerardi V made figures and wrote the paper; Stojanovic J and Poscia A performed the metanalysis; all authors contributed to data interpretation, editing.
Conflict-of-interest statement: Scaldaferri F and Gasbarrini A were consultants for Ca.Digroup; however, each author has no financial interests or connections, direct or indirect, or other situations that might raise the question of bias in the work reported or the conclusions.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Franco Scaldaferri, MD, PhD, Centre for the Research and Cure of Inflammatory Bowel Disease, UOC di Medicina Interna e Gastroenterologia, Institute of Medical Pathology, Catholic University of the Sacred Hearth, Fondazione Policlinico “A. Gemelli” Hospital, lgo Gemelli 8, 00168 Roma, Italy. francoscaldaferri@gmail.com
Telephone: +39-6-30155923 Fax: +39-6-30157249
Received: January 11, 2016
Peer-review started: January 13, 2016
First decision: February 18, 2016
Revised: March 12, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 28, 2016
Peer-review started: January 13, 2016
First decision: February 18, 2016
Revised: March 12, 2016
Accepted: May 4, 2016
Article in press: May 4, 2016
Published online: June 28, 2016
Core Tip
Core tip:Escherichia coli (E. coli) Nissle is a nonpathogenic Gram-negative strain used as a probiotic with very good quality paper assessing its bio-equivalence to mesalazine in maintaining remission in ulcerative colitis. Mechanisms of actions of this compound include immune-modulatory properties, reinforcement of intestinal barrier and inhibitory effect towards other pathogenic E. coli.