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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2016; 22(19): 4707-4715
Published online May 21, 2016. doi: 10.3748/wjg.v22.i19.4707
Published online May 21, 2016. doi: 10.3748/wjg.v22.i19.4707
Laparoscopic colonic anastomosis using a degradable stent in a porcine model
Liang Ma, Yan-Lan Yu, Guang-Ju Ge, Hai-Yi Hu, Shi-Cheng Yu, Department of Gastroenterology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China
Xiu-Jun Cai, Di-Yu Huang, Department of General Surgery, Sir Run Run Shaw Hospital and The Institute of Minimally Invasive Surgery, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China
Hai-Hong Wang, Department of Anesthesia, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang Province, China
Author contributions: Ma L performed the majority of experiments and analyzed the data; Ma L, Wang HH, Huang DY, Ge GJ, Hu HY and Yu SC contributed equally to treatment of animals; Cai XJ and Ma L designed and coordinated the research; Ma L and Yu YL wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Sir Run Run Shaw Hospital, Hangzhou, China.
Institutional animal care and use committee statement: All procedures were carried out according to the Institutional Animal Care and Use Committee Guide of Center for Drug Safety Evaluation and Research of Zhejiang University with the following reference number: IACUC-13001.
Conflict-of-interest statement: None of the authors disclosed any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xiu-Jun Cai, MD, Department of General Surgery, Sir Run Run Shaw Hospital and The Institute of Minimally Invasive Surgery, Zhejiang University School of Medicine, No 3, East Qinchun Road, Hangzhou 310016, Zhejiang Province, China. srrshurology@163.com
Telephone: +86-571-86006605 Fax: +86-571-86006605
Received: January 18, 2016
Peer-review started: January 20, 2016
First decision: February 18, 2016
Revised: March 2, 2016
Accepted: March 14, 2016
Article in press: March 14, 2016
Published online: May 21, 2016
Peer-review started: January 20, 2016
First decision: February 18, 2016
Revised: March 2, 2016
Accepted: March 14, 2016
Article in press: March 14, 2016
Published online: May 21, 2016
Core Tip
Core tip: We explored the feasibility and safety of laparoscopic colonic anastomosis using a degradable stent in a porcine model. Twenty Bama mini-pigs were randomly assigned to a stent group and hand-sewn anastomosis group. The operation and anastomotic completion times of the stent group were significantly shorter than those of the control group. There was no significant difference between the anastomotic and normal circumference in the stent group. No intestinal leakage and luminal stenosis occurred in the stent group. Histological examination of anastomoses revealed that the stent group presented with less general inflammation and better healing than the control group.