Published online May 21, 2016. doi: 10.3748/wjg.v22.i19.4638
Peer-review started: January 11, 2016
First decision: March 21, 2016
Revised: April 1, 2016
Accepted: April 20, 2016
Article in press: April 20, 2016
Published online: May 21, 2016
Core tip: Among various cellular signaling pathways, hepatocyte growth factor/c-MET, phosphoinositide 3-kinase/Akt/mammalian target of rapamycin and janus kinase 2/signal transducer and activator of transcription 3 pathways are reportedly important in gastric carcinogenesis and metastasis. Aberrations of immune checkpoints have been vigorously investigated. However, clinical results of their target agents have not always matched the theoretical expectations of efficacy. In this review, we summarize the biologic impacts of the aforementioned signaling pathways, and their recent clinical outcomes including those of multiple kinase inhibitors in gastric cancer.