Relationship between indoleamine 2,3-dioxygenase activity and lymphatic invasion propensity of colorectal carcinoma
Atilla Engin, Ahmet Karamercan, Department of General Surgery, Faculty of Medicine, Gazi University, TR 06500 Beşevler, Ankara, Turkey
Ipek Isik Gonul, Ayse Dursun, Department of Pathology, Faculty of Medicine, Gazi University, TR 06500 Beşevler, Ankara, Turkey
Ayse Basak Engin, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara, Turkey
Aylin Sepici Dincel, Department of Biochemistry, Faculty of Medicine, Gazi University, TR 06500 Beşevler, Ankara, Turkey
Author contributions: Engin A designed and co-ordinated the study, selected the patients, did surgical interventions and wrote the manuscript; Gonul II and Dursun A did the immunohistochemical staining and analysis; Karamercan A involved in surgical interventions; Engin AB and Sepici Dincel A performed the experiments; and Engin AB involved in editing the manuscript.
Supported by Gazi University, Scientific Research Projects Division, No. 01/2007-62.
Institutional review board statement: The study was approved by Gazi University, Local Ethics Committee.
Informed consent statement: All participants’ rights were protected and informed consents were obtained according to the Helsinki Declaration.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Ayse Basak Engin, Associate Professor, Department of Toxicology, Faculty of Pharmacy, Gazi University, TR 06330 Hipodrom, Ankara, Turkey. email@example.com
Telephone: +90-312-2023084 Fax: +90-312-2222326
Received: September 11, 2015
Peer-review started: September 14, 2015
First decision: January 13, 2016
Revised: January 31, 2016
Accepted: March 2, 2016
Article in press: March 2, 2016
Published online: April 7, 2016