Serum vitamin D and colonic vitamin D receptor in inflammatory bowel disease
Yamilka Abreu-Delgado, Esther A Torres, Alexandra González, Priscilla Medero, Division of Gastroenterology, Department of Medicine, University of Puerto Rico Medical Sciences Campus-School of Medicine, San Juan, PR 00935, United States
Raymond A Isidro, Myrella L Cruz, Angel A Isidro, Caroline B Appleyard, Department of Basic Sciences, Physiology Division, Ponce Health Sciences University-Medical School and Ponce Research Institute, Ponce, PR 00732, United States
Carmen I González-Keelan, Department of Pathology and Laboratory Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00935, United States
Author contributions: Abreu-Delgado Y and Isidro RA contributed equally to this work; Abreu-Delgado Y, Isidro RA, Torres EA and Appleyard CB designed the research; Abreu-Delgado Y, Torres EA, González A and Medero P recruited subjects and collected material and clinical data; Isidro RA, Cruz ML, Isidro AA and González-Keelan CI performed the assays and analyzed the tissue samples; Abreu-Delgado Y, Isidro RA and Appleyard CB drafted the manuscript; Torres EA, González A, Cruz ML, Isidro AA, González-Keelan CI and Medero P critically revised manuscript for important intellectual content.
Supported by National Institutes of Health Grants, No. R25GM082406 (to Isidro RA); and U54CA163071 to Appleyard CB; the Office of Research from the Ponce Research Institute at Ponce Health Sciences University; William Townsend Porter Predoctoral Fellowship from the American Physiological Society (to Isidro RA); the PHSU Molecular and Genomics Core Laboratory, RCMI Grant No. RR003050/MD007579; the Puerto Rico Clinical and Translational Research Consortium, National Institutes of Health Grant U54MD007587 (to Abreu Y, Medero P and Torres EA).
Institutional review board statement: The study was reviewed and approved by the University of Puerto Rico Medical Sciences Campus Institutional Review Board (protocol number 1250313).
Informed consent statement: All subjects gave written informed consent prior to study inclusion.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Caroline B Appleyard, PhD, Professor, Department of Basic Sciences, Physiology Division, Ponce Health Sciences University-Medical School and Ponce Research Institute, PO Box 7004, Ponce, PR 00732, United States. email@example.com
Telephone: +1-787-8402575 Fax: +1-787-8413736
Received: October 24, 2015
Peer-review started: October 26, 2015
First decision: November 13, 2015
Revised: December 5, 2015
Accepted: January 18, 2016
Article in press: January 18, 2016
Published online: April 7, 2016