Basic Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 7, 2016; 22(13): 3573-3580
Published online Apr 7, 2016. doi: 10.3748/wjg.v22.i13.3573
Analysis of tumor-infiltrating gamma delta T cells in rectal cancer
Liang Rong, Ke Li, Rui Li, Hui-Min Liu, Rui Sun, Xiao-Yan Liu
Liang Rong, Ke Li, Hui-Min Liu, Rui Sun, Xiao-Yan Liu, Department of Gastroenterology, the Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Rui Li, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu Province, China
Author contributions: Rong L designed the study; Li K performed the research; Liu HM contributed new reagents and analytic tools; Rong L and Sun R analyzed the data; Rong L and Li K wrote the paper; all the authors contributed to this manuscript.
Institutional review board statement: The study was revised and approved by the Fifth Affiliated Hospital of Xinjiang Medical University Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the First Affiliated Hospital of Soochow University (IACUC protocol number: 2013-10-13).
Conflict-of-interest statement: We declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Rui Li, MD, Department of Gastroenterology, the First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou 215006, Jiangsu Province, China. rongliangrl@yeah.net
Telephone: +86-512-65223637 Fax: +86-512-65223637
Received: November 1, 2015
Peer-review started: November 2, 2015
First decision: November 27, 2015
Revised: December 14, 2015
Accepted: January 11, 2016
Article in press: January 11, 2016
Published online: April 7, 2016
Core Tip

Core tip: The percentage of tumor-infiltrating Vδ1 T cells in rectal cancer patients increased when T stage increased, whereas the percentage of tumor-infiltrating Vδ2 T cells in rectal cancer patients decreased as T stage increased. Vδ1 T cells from rectal cancer tissues had strong regulatory effects, and in rectal cancer tissues the main infiltrating γδ T cells were Vδ1 T cells. Although Vδ2 T cells from rectal cancer tissues have strong cytotoxic effects, there was little infiltration of Vδ2 T cells in rectal cancer tissues. Thus, an immunosuppressant microenvironment was formed in rectal cancer tissues, which may limit antitumor immunity and allow tumors in rectal cancer patients to evade immune surveillance.