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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2016; 22(12): 3460-3470
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3460
Published online Mar 28, 2016. doi: 10.3748/wjg.v22.i12.3460
Cost-effectiveness analysis of population-based screening of hepatocellular carcinoma: Comparing ultrasonography with two-stage screening
Ming-Jeng Kuo, Department of Hepatogastroenterology, Tainan Municipal Hospital, Tainan 701, Taiwan
Hsiu-Hsi Chen, Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan
Chi-Ling Chen, Graduate Institute of Clinical Medicine, College of Medicine, and Graduate Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100, Taiwan
Jean Ching-Yuan Fann, Department of Health Industry Management, School of Healthcare Management, Kainan University, Taoyuan 338, Taiwan
Sam Li-Sheng Chen, Amy Ming-Fang Yen, School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
Sherry Yueh-Hsia Chiu, Department and Graduate Institute of Health Care Management, Chang Gung University, Taoyuan 333, Taiwan
Yu-Min Lin, Hung-Chuen Chang, Yueh-Shih Lin, Division of Gastroenterology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan
Chao-Sheng Liao, Yangder Health Clinics, Taipei 111, Taiwan
Author contributions: Kuo MJ, Chen HH, and Yen AMF designed the study and drafted the article; Kuo MJ and Yen AMF were responsible for model construction, collection of parameters, and interpretation of the results; Kuo MJ, Chen HH, Chen CL, Fann JCY, Chen SLS, Chiu SYH, Lin YM, Chang HC, and Liao CC made critical revision of the article for important intellectual content; and all authors approved the final version of the article.
Supported by Kaohsiung Municipal Min-Seng Hospital (KMSH 9702).
Conflict-of-interest statement: The authors had no conflict of interest to declare.
Data sharing statement: No further data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Amy Ming-Fang Yen, School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, No.250, Wu-Hsing Street, Xinyi District, Taipei 110, Taiwan. amyyen@tmu.edu.tw
Telephone: +886-2-27361661-5152 Fax: +886-2-27398004
Received: July 31, 2015
Peer-review started: August 3, 2015
First decision: September 9, 2015
Revised: September 29, 2015
Accepted: December 19, 2015
Article in press: December 21, 2015
Published online: March 28, 2016
Peer-review started: August 3, 2015
First decision: September 9, 2015
Revised: September 29, 2015
Accepted: December 19, 2015
Article in press: December 21, 2015
Published online: March 28, 2016
Core Tip
Core tip: Hepatocellular carcinoma (HCC) mortality could be reduced by early detection. Previous studies have investigated the cost-effectiveness of different surveillance intervals and screening modalities but were restricted to high risk populations. We conducted a cost-effectiveness analysis of mass screening for HCC with abdominal ultrasonography for the general population and compared it to the existing two-stage biomarker-ultrasound screening in an area with high HCC incidence. The findings suggest early detection of HCC with abdominal ultrasonography may be useful for the general population in an area with high HCC incidence not covered by hepatitis B vaccination.