Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2015; 21(9): 2651-2657
Published online Mar 7, 2015. doi: 10.3748/wjg.v21.i9.2651
Are gastric mucosal macrophages responsible for gastric injury in acute pancreatitis?
Sheng-Chun Dang, Hao Wang, Jian-Xin Zhang, Lei Cui, De-Li Jiang, Rong-Fang Chen, Jian-Guo Qu, Xiang-Qian Shen, Min Chen, Min Gu
Sheng-Chun Dang, Hao Wang, Jian-Xin Zhang, Lei Cui, Rong-Fang Chen, Jian-Guo Qu, Department of General Surgery, the Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
De-Li Jiang, Min Chen, School of Chemistry and Chemical Engineering of Jiangsu University, Zhenjiang 212013, Jiangsu Province, China
Xiang-Qian Shen, Institute for Advanced Materials, Jiangsu University, Zhenjiang 212013, Jiangsu Province, China
Min Gu, Zhengjang Integrative Medicine Hospital, Zhenjiang 212001, Jiangsu Province, China
Author contributions: Dang SC, Zhang JX and Gu M contributed equally to this work; Dang SC and Zhang JX designed the research; Dang SC, Wang H, Cui L, Chen RF, Qu JG and Shen XQ performed the research; Jiang DL and Chen M prepared the liposomes; Dang SC analyzed the data; Dang SC and Gu M wrote the paper.
Supported by Jiangsu Planned Projects for Postdoctoral Research Funds, No. 1302096B; and Natural Science Foundation of Jiangsu Province, No. BK2011484 and No. 2012704; National Natural Science Foundation of China, No. 81070287.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sheng-Chun Dang, MD, Department of General Surgery, the Affiliated Hospital of Jiangsu University, No. 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, China. dscgu@163.com
Telephone: +86-511-88820988 Fax: +86-511-88820988
Received: September 6, 2014
Peer-review started: September 7, 2014
First decision: October 14, 2014
Revised: November 2, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: March 7, 2015
Core Tip

Core tip: In this study, we investigated the protective effect of clodronate liposomes against severe acute pancreatitis (SAP)-triggered acute gastric mucosal injury in rats. Our results revealed that gastric macrophages are involved in the pathogenesis of gastric injury in SAP. Moreover, clodronate-containing liposomes have protective effects against gastric mucosal injury in rats with SAP. Therefore, the blockade of macrophage infiltration may represent a novel therapeutic strategy for the treatment of SAP.