Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1718
Peer-review started: August 28, 2014
First decision: September 15, 2014
Revised: October 25, 2014
Accepted: December 5, 2014
Article in press: December 8, 2014
Published online: February 14, 2015
Core tip: Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disease and its pathogenesis is closely linked to the metabolic syndrome. Vitamin D deficiency, which also shares similar associations with obesity and sedentary lifestyle, is often found together with NAFLD. As our understanding of the many functions of vitamin D has grown, emerging evidence points to a closely linked and potentially causative relationship between vitamin D deficiency and NAFLD. As such, vitamin D is now emerging as an immunomodulatory and anti-fibrotic agent. However, in order to implement clinical recommendations larger, randomized, placebo-control trials are required to better evaluate the efficacy of vitamin D replacement in NAFLD.