Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2015; 21(48): 13466-13472
Published online Dec 28, 2015. doi: 10.3748/wjg.v21.i48.13466
Effect of gingerol on colonic motility via inhibition of calcium channel currents in rats
Zheng-Xu Cai, Xu-Dong Tang, Feng-Yun Wang, Zhi-Jun Duan, Yu-Chun Li, Juan-Juan Qiu, Hui-Shu Guo
Zhi-Jun Duan, Yu-Chun Li, Juan-Juan Qiu, Hui-Shu Guo, Central Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Zheng-Xu Cai, Department of Internal Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China
Xu-Dong Tang, Feng-Yun Wang, Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
Author contributions: Cai ZX and Tang XD contributed equally to this work; Guo HS designed the research; Cai ZX, Tang XD and Wang FY performed the research; Duan ZJ, Li YC and Qiu JJ analyzed the data and revised the manuscript; Guo HS and Cai ZX wrote the paper.
Supported by National Basic Research Program of China (973 Program), No. 2013CB531703; National Natural Science Foundation of China, No. 81273919; and Natural Science Foundation of Liaoning Province, No. 2012225020 and No. 2013023002.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Animal Care and Use Committee of the Dalian Medical University [License No.: SCXK (LIAO) 2008-0002; certificate No. 0003496].
Conflict-of-interest statement: To the best of our knowledge, no conflict of interest exists.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hui-Shu Guo, PhD, Professor, Chief, Central Laboratory, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Lu, Dalian 116011, Liaoning Province, China. guohuishu1@126.com
Telephone: +86-411-83635963-2238 Fax: +86-411-83622844
Received: June 3, 2015
Peer-review started: June 6, 2015
First decision: July 10, 2015
Revised: July 24, 2015
Accepted: August 28, 2015
Article in press: August 29, 2015
Published online: December 28, 2015
Core Tip

Core tip: Gingerol, a non-pungent molecule, has an inhibitory effect on colonic motility. There are many ion channels and second messengers involved in this process; however, no reports have described the effects of gingerol on L-type calcium channel currents. In the present study, we found that 6-gingerol obviously inhibited spontaneous contraction of longitudinal smooth muscle by preventing Ca2+ influx through L-type calcium channels.