Wang YXJ. Current status of superparamagnetic iron oxide contrast agents for liver magnetic resonance imaging. World J Gastroenterol 2015; 21(47): 13400-13402 [PMID: 26715826 DOI: 10.3748/wjg.v21.i47.13400]
Corresponding Author of This Article
Yi-Xiang J Wang, PhD, MMed, Department of Imaging and Interventional Radiology, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. yixiang_wang@cuhk.edu.hk
Research Domain of This Article
Radiology, Nuclear Medicine & Medical Imaging
Article-Type of This Article
Letters To The Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Dec 21, 2015; 21(47): 13400-13402 Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13400
Current status of superparamagnetic iron oxide contrast agents for liver magnetic resonance imaging
Yi-Xiang J Wang
Yi-Xiang J Wang, Department of Imaging and Interventional Radiology, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China
Author contributions: Wang YXJ designed research, analyzed data, and wrote the paper.
Conflict-of-interest statement: The author declares no conflict-of-interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Yi-Xiang J Wang, PhD, MMed, Department of Imaging and Interventional Radiology, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China. yixiang_wang@cuhk.edu.hk
Telephone: +852-26322289
Received: May 28, 2015 Peer-review started: May 31, 2015 First decision: August 26, 2015 Revised: September 15, 2015 Accepted: November 9, 2015 Article in press: November 9, 2015 Published online: December 21, 2015
Core Tip
Core tip: Superparamagnetic iron oxide nanoparticle for liver imaging was conceptualized when the speed of both single-slice computed tomography (CT) scan and multiple-slice magnetic resonance imaging (MRI) was slow. It was difficult to accurately observe the “wash-in” and “wash-out” of liver lesion blood flow dynamics. However, recently spiral CT and later multi-slice CT revolutionized liver imaging. MRI scan is also currently much faster due to the improved gradient technology and fast data acquisition sequences. These techniques increased the sensitivity and specificity of dynamic imaging using small molecular agents such as iodinated CT contrast agents and Gadolinium based MRI contrast agents. Gd-EOB-DTPA-enhanced liver MRI is currently emerging as the leading method for diagnosis and staging of hepatocellular carcinoma.
