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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 21, 2015; 21(47): 13250-13258
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13250
Published online Dec 21, 2015. doi: 10.3748/wjg.v21.i47.13250
Protective role of adiponectin in a rat model of intestinal ischemia reperfusion injury
Xu-Hui Liu, Hai-Tao Dai, Rui-Han Chen, Zhi-Qiang Ye, Department of Emergency Care, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Yue-Wu Yang, Department of Traditional Chinese Medicine, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Song-Wang Cai, Department of Cardiothoracic Surgery, the Third Affiliated Hospital of Sun, Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Author contributions: Liu XH, Yang YW and Dai HT contributed equally to this work; Ye ZQ designed research; Liu XH and Yang YW performed research; Dai HT and Cai SW contributed new reagents or analytical tools; Chen RH analyzed data; Liu XH and Yang YW wrote the paper.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China. The animal protocol was designed to minimize pain or discomfort to the animals.
Conflict-of-interest statement: The authors declared no conflicts of interest in this study.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Zhi-Qiang Ye, Department of Emergency Care, the Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tianhe Street, Guangzhou 510630, Guangdong Province, China. yezhiqiang150211@163.com
Telephone: +86-20-85253010 Fax: +86-20-85252553
Received: March 3, 2015
Peer-review started: March 5, 2015
First decision: May 18, 2015
Revised: June 21, 2015
Accepted: September 2, 2015
Article in press: September 2, 2015
Published online: December 21, 2015
Peer-review started: March 5, 2015
First decision: May 18, 2015
Revised: June 21, 2015
Accepted: September 2, 2015
Article in press: September 2, 2015
Published online: December 21, 2015
Core Tip
Core tip: Serum adiponectin was downregulated in the rat model of intestinal ischemia reperfusion (I/R) injury, and adiponectin pre-treatment attenuated intestinal I/R injury in rats. While the underlying mechanism of adiponectin-induced protection against intestinal I/R injury is not fully understood, the results of the present study suggest that the AMP-activated protein kinase (AMPK)/heme oxygenase 1 (HO-1) signaling pathway may be involved in this process. Therefore, adiponectin and components of the AMPK/HO-1 signaling pathway may be promising targets in the treatment of intestinal I/R injury.