Management of entecavir-resistant chronic hepatitis B with adefovir-based combination therapies
Hyoung Su Kim, Myoung Kuk Jang, Ji Won Park, Department of Internal Medicine, Hallym University College of Medicine, Seoul 134-701, South Korea
Hyung Joon Yim, Sang Jun Suh, Young Kul Jung, Department of Internal Medicine, Korea University Ansan Hospital, Ansan 425-707, South Korea
Yeon Seok Seo, Ji Hoon Kim, Department of Internal Medicine, Korea University Medical College, Seoul 136-705, South Korea
Bo Hyun Kim, Sang Jong Park, Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam 463-774, South Korea
Sae Hwan Lee, Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Cheonan 330-721, South Korea
Sang Gyune Kim, Young Seok Kim, Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Bucheon 330-721, South Korea
Jung Il Lee, Jin-Woo Lee, Department of Internal Medicine, Inha University School of Medicine, Incheon 400-711, South Korea
In Hee Kim, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju 561-712, South Korea
Tae Yeob Kim, Department of Internal Medicine, Hanyang University College of Medicine, Guri 471-701, South Korea
Jin-Wook Kim, Sook-Hyang Jeong, Department of Internal Medicine, Seoul National University College of Medicine, Seongnam 463-707, South Korea
Young Kul Jung, Department of Internal Medicine, Gachon University School of Medicine, Incheon 405-760, South Korea
Hana Park, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea
Author contributions: Kim HS, Yim HJ and Hwang SG designed the research; Kim HS, Yim HJ, Jang MK, Park JW, Suh SJ, Seo YS, Kim JH, Kim BH, Park SJ, Lee SH, Kim SG, Kim YS, Lee JI, Lee JW, Kim IH, Kim TY, Kim JW, Jeong SH, Jung YK, Park H and Hwang SG performed research; Yim HJ collected data; Kim HS analyzed the data and wrote the paper; and Yim HJ and Hwang SG share corresponding authorship.
Supported by Research Funds from the Korean Association for the Study of the Liver (in part).
Institutional review board statement: The study was reviewed and approved by the local ethics committee (Korea University Ansan Hospital, approval No. AS11102-001).
Informed consent statement: All participants provided written informed consent prior to study enrollment.
Conflict-of-interest statement: The authors have no conflicts of interest to declare with respect to this manuscript.
Data sharing statement: Participants gave informed consent for data sharing. Technical appendix, statistical code, and dataset are available from one of the corresponding author at firstname.lastname@example.org. No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hyung Joon Yim, MD, PhD, Department of Internal Medicine, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-Gu, Ansan-Si, Gyeonggi-Do 425-707, South Korea. email@example.com
Telephone: +82-31-4126565 Fax: +82-31-4125582
Received: February 2, 2015
Peer-review started: February 5, 2015
First decision: March 26, 2015
Revised: May 13, 2015
Accepted: July 18, 2015
Article in press: July 18, 2015
Published online: October 14, 2015