Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Sep 21, 2015; 21(35): 10166-10173
Published online Sep 21, 2015. doi: 10.3748/wjg.v21.i35.10166
Xanthogranulomatous cholecystitis: Difficulty in differentiating from gallbladder cancer
Hideki Suzuki, Satoshi Wada, Kenichiro Araki, Norio Kubo, Akira Watanabe, Mariko Tsukagoshi, Hiroyuki Kuwano
Hideki Suzuki, Satoshi Wada, Kenichiro Araki, Norio Kubo, Akira Watanabe, Mariko Tsukagoshi, Hiroyuki Kuwano, Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan
Author contributions: Suzuki H and Kuwano H designed the research; Suzuki H wrote the paper; Wada S, Araki K and Kubo N performed the research; Watanabe A and Tsukagoshi M analyzed the data.
Institutional review board statement: This study is not a formal study with a protocol; therefore, no submission was made the Hospital Ethics Review Board.
Informed consent statement: In this retrospective study, written informed consent was not provided by the participants, but the presented data are anonymized and risk of identification is low.
Conflict-of-interest statement: None of the authors of this manuscript have any conflicts of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at hidesuzuki044@gmail.com. Participants gave informed consent for data sharing.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hideki Suzuki, MD, Department of General Surgical Science (Surgery I), Gunma University Graduate School of Medicine, Gunma University, 3-39-22 Showa-machi, Maebashi 371-8511, Japan. hidesuzuki044@gmail.com
Telephone: +81-272-208224 Fax: +81-272-208230
Received: March 20, 2015
Peer-review started: March 25, 2015
First decision: April 23, 2015
Revised: May 13, 2015
Accepted: July 18, 2015
Article in press: July 18, 2015
Published online: September 21, 2015
Core Tip

Core tip: Xanthogranulomatous cholecystitis (XGC) is a rare inflammatory disease of the gallbladder. Differentiating between XGC and malignant gallbladder lesions is often difficult, especially in patients with severe proliferative fibrosis involving the gallbladder and surrounding organs. We compared the clinical features and computed tomography findings between patients with XGC and patients with advanced gallbladder cancer. There were almost no significant differences between the two groups. Although XGC is often difficult to differentiate from gallbladder carcinoma, it is possible to obtain an accurate diagnosis by careful intraoperative gross observation and several intraoperative frozen sections which could prevent extended resections.