Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 14, 2015; 21(30): 8985-8993
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.8985
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.8985
Signs and genetics of rare cancer syndromes with gastroenterological features
William Bruno, Paola Ghiorzo, Genetics of Rare Cancers, Department of Internal Medicine and Medical Specialties, University of Genoa, IRCCS AOU San Martino-IST, 16132 Genoa, Italy
Giuseppe Fornarini, Medical Oncology Unit, IRCCS AOU San Martino-IST, 16132 Genoa, Italy
Author contributions: Bruno W designed and wrote the manuscript; Fornarini G reviewed the associated cancer risk; Ghiorzo P conceptualized, designed and reviewed the manuscript; all authors reviewed the manuscript critically for intellectual content and approved the final version.
Supported by Grants from the Italian Ministry of Health, 5 per 1000, AIRC 15460 and Genoa Atheneum 2014 (to Ghiorzo P).
Conflict-of-interest statement: The authors decalre no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: William Bruno, MD, PhD, Genetics of Rare Cancers, Department of Internal Medicine and Medical Specialties, University of Genoa, IRCCS AOU San Martino-IST, V.le Benedetto XV 6, 16132 Genoa, Italy. william.bruno@unige.it
Telephone: +39-1-3537913 Fax: +39-1-3538887
Received: February 27, 2015
Peer-review started: February 28, 2015
First decision: April 27, 2015
Revised: May 26, 2015
Accepted: July 15, 2015
Article in press: July 15, 2015
Published online: August 14, 2015
Peer-review started: February 28, 2015
First decision: April 27, 2015
Revised: May 26, 2015
Accepted: July 15, 2015
Article in press: July 15, 2015
Published online: August 14, 2015
Core Tip
Core tip: Close collaboration between geneticists and gastroenterologists can facilitate early identification of patients or relatives at-risk and the planning of multidisciplinary and tailored management. This editorial summarizes the diagnostic criteria, cancer associations and genetic bases of very rare cancer syndromes whose clinical features include gastroenterological signs.