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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Aug 7, 2015; 21(29): 8776-8786
Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8776
Published online Aug 7, 2015. doi: 10.3748/wjg.v21.i29.8776
Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2
Satoshi Tanida, Tsutomu Mizoshita, Keiji Ozeki, Takahito Katano, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya city Aichi prefecture, Aichi 467-8601, Japan
Author contributions: Tanida S study concept, data acquisition, data analysis, drafting of the manuscript; Kataoka H, Kamiya T and Joh T study concept, supervision; Mizoshita T, Ozeki K and Katano T technical support and data analysis.
Supported by Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science, No. 25460957.
Conflict-of-interest statement: All authors declare that there are no conflicts of interest regarding this work.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Satoshi Tanida, MD, PhD, Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya city Aichi prefecture, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. stanida@med.nagoya-cu.ac.jp
Telephone: +81-52-8538211 Fax: +81-52-8520952
Received: April 2, 2015
Peer-review started: April 4, 2015
First decision: April 23, 2015
Revised: May 8, 2015
Accepted: July 8, 2015
Article in press: July 8, 2015
Published online: August 7, 2015
Peer-review started: April 4, 2015
First decision: April 23, 2015
Revised: May 8, 2015
Accepted: July 8, 2015
Article in press: July 8, 2015
Published online: August 7, 2015
Core Tip
Core tip: The main goal of ulcerative colitis (UC) therapy is to induce and maintain long-term corticosteroid-free remission. Therapies such as anti-tumor necrosis factor (TNF)-α and integrin α4β7 neutralizing antibodies have emerged in recent times, but are not universally efficacious; additional treatments are needed. We have recently demonstrated that annexin (ANX) A2 inhibition may be a new therapeutic strategy to prevent TNF-α shedding during inflammatory bowel disease (IBD) inflammation. Here we focus on effective therapies for UC patients that are currently available, or will be in the near future, and the potential of ANX A2 as a new molecular target for IBD treatment.