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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2015; 21(26): 8081-8088
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.8081
Published online Jul 14, 2015. doi: 10.3748/wjg.v21.i26.8081
Ischemic preconditioning ameliorates intestinal injury induced by ischemia-reperfusion in rats
Yuan-Yuan Ji, Scientific Research Centre, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Zhi-Dong Wang, Bao-Tai Wang, Zheng-An Yang, Xiao-Rong Zhou, Ni-Na Lei, Wei-Na Yue, Department of VIP General Surgery, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710004, Shaanxi Province, China
Shu-Feng Wang, Department of General Surgery, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Ji YY and Wang ZD contributed equally to this work; Ji YY and Wang ZD performed the research and wrote the paper; Ji YY, Wang ZD, Wang SF, Wang BT, Yang ZA and Zhou XR designed the research and analyzed the data; Lei NN and Yue WN contributed materials and methods.
Supported by Grants from the Fundamental Research Funds for the Central Universities, No. 2013JDHZ08; and Personnel training Specialized Research Fundation of The Second Affiliated Hospital of Xi’an Jiaotong University of China, No. RC(GG)201404.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Xi’an Jiaotong University, China.
Institutional animal care and use committee statement: All animal experiments were carried out in accordance with the Animal Care Committee of Xi’an Jiaotong University, China.
Conflict-of-interest statement: The authors have no competing interests.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Zhi-Dong Wang, Department of VIP General Surgery, The Second Affiliated Hospital, Xi’an Jiaotong University, No. 157 West 5th Road, Xi’an 710004, Shaanxi Province, China. xawzd@163.com
Telephone: +86-29-87679208 Fax: +86-29-87679208
Received: February 4, 2015
Peer-review started: February 6, 2015
First decision: April 13, 2015
Revised: April 26, 2015
Accepted: May 20, 2015
Article in press: May 21, 2015
Published online: July 14, 2015
Peer-review started: February 6, 2015
First decision: April 13, 2015
Revised: April 26, 2015
Accepted: May 20, 2015
Article in press: May 21, 2015
Published online: July 14, 2015
Core Tip
Core tip: Although intestinal ischemic preconditioning (IP) triggers powerful protective effects, particularly in surgical ischemic operation and transplantation, mechanisms by which IP alleviates intestinal injury remain to be elucidated. The present study found that IP protects against intestinal ischemia-reperfusion-induced injury by reducing intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression, and tumor necrosis factor-α-induced nuclear factor-κB signaling pathway activity. The results suggest that intestinal IP may be clinically useful in the future to treat patients with intestinal ischemia-reperfusion-induced injury.