Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7412
Peer-review started: January 14, 2015
First decision: March 26, 2015
Revised: April 10, 2015
Accepted: May 20, 2015
Article in press: May 21, 2015
Published online: June 28, 2015
Core tip: Hepatitis C virus (HCV) infection is a significant threat to the health of elderly patients, in whom liver disease progresses very rapidly and extrahepatic complications affect the quality of life. Till now, treatment attempts have been substantially limited by the side effects of interferon (IFN). Here we discuss how the availability of IFN-free regimens should prompt us to change our mind when assessing treatment indication and to consider a significantly larger number of possible candidates among elderly patients. Drug-drug interactions and assessment of liver disease-dependent vs comorbidities-dependent life expectancy, rather than anagraphic age, are likely to guide the choice of the aged HCV patients to be treated in the next future.