Lamontagne J, Steel LF, Bouchard MJ. Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases. World J Gastroenterol 2015; 21(24): 7375-7399 [PMID: 26139985 DOI: 10.3748/wjg.v21.i24.7375]
Corresponding Author of This Article
Michael J Bouchard, PhD, Department of Biochemistry, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, United States. michael.bouchard@drexelmed.edu
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 28, 2015; 21(24): 7375-7399 Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7375
Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases
Jason Lamontagne, Laura F Steel, Michael J Bouchard
Jason Lamontagne, Microbiology and Immunology Graduate Program, Graduate School of Biomedical Sciences and Professional Studies, Drexel University College of Medicine, Philadelphia, PA 19102, United States
Laura F Steel, Department of Microbiology and Immunology, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, Philadelphia, PA 19102, United States
Michael J Bouchard, Department of Biochemistry, Drexel University College of Medicine, Philadelphia, PA 19102, United States
Author contributions: Lamontagne J, Steel LF, and Bouchard MJ solely contributed to this paper.
Supported by Pennsylvania state CURE grant, No. 4100057658, [to Steel LF and Bouchard MJ (partially)]; and a Ruth L Kirschstein (F31) Predoctoral Fellowship, No. 5F31CA171712-03, [to Lamontagne J (partially)].
Conflict-of-interest: The authors report no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Michael J Bouchard, PhD, Department of Biochemistry, Drexel University College of Medicine, 245 N 15th Street, Philadelphia, PA 19102, United States. michael.bouchard@drexelmed.edu
Telephone: +1-866-373-9352
Received: January 15, 2015 Peer-review started: January 15, 2015 First decision: March 10, 2015 Revised: March 25, 2015 Accepted: May 20, 2015 Article in press: May 21, 2015 Published online: June 28, 2015
Core Tip
Core tip: In this review, we discuss the current state of our understanding of how hepatitis B virus (HBV) affects the expression profile of cellular microRNAs (miRNAs), how these miRNAs impact HBV replication, and the relationship between HBV-mediated miRNA regulation and hepatocellular carcinoma development. Importantly, we address challenges in studying the relationship between HBV and miRNAs, including the lack of an experimental system that effectively models HBV infection and a reliance on the use of transformed cell lines. Finally, we propose applications of techniques to address the functional impact of HBV-mediated regulation of miRNA expression, which could enhance our understanding of the role miRNAs play in HBV replication and disease.
