Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 28, 2015; 21(24): 7362-7366
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7362
Published online Jun 28, 2015. doi: 10.3748/wjg.v21.i24.7362
Immunomodulation of enteric neural function in irritable bowel syndrome
Dervla O’Malley, Department of Physiology and Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland
Author contributions: O’Malley D solely contributed to this paper.
Conflict-of-interest: The author has no financial, professional or personal conflicts relating to this publication.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Dervla O’Malley, Department of Physiology and Alimentary Pharmabiotic Centre, University College Cork, 4.23 Western Gateway Building, Cork, Ireland. d.omalley@ucc.ie
Telephone: +353-21-4205483 Fax: +353-21-4205370
Received: January 7, 2015
Peer-review started: January 8, 2015
First decision: January 22, 2015
Revised: February 3, 2015
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: June 28, 2015
Peer-review started: January 8, 2015
First decision: January 22, 2015
Revised: February 3, 2015
Accepted: March 12, 2015
Article in press: March 12, 2015
Published online: June 28, 2015
Core Tip
Core tip: This article assesses the importance of neuroimmune modulation of gastrointestinal function in the functional bowel disorder, irritable bowel syndrome (IBS). Recent progress in understanding the molecular mechanisms underlying the pathophysiology of IBS reveals the neuromodulatory effects of mast cell mediators, cytokines and luminal microbiota.