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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 21, 2015; 21(23): 7313-7319
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7313
Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7313
Increased risk of second malignancy in pancreatic intraductal papillary mucinous tumors: Review of the literature
Gian Luca Baiocchi, Sarah Molfino, Federico Gheza, Giacomo Gaverini, Antonio Tarasconi, Guido AM Tiberio, Nazario Portolani, Department of Medical and Surgical Sciences, Surgical Clinic, University of Brescia, 25123 Brescia, Italy
Barbara Frittoli, Luigi Grazioli, 1st Department of Radiology, Brescia Civil Hospital, 25123 Brescia, Italy
Graziella Pigozzi, Chiara Ricci, Department of Medical and Surgical Sciences, Gastroenterological Unit, University of Brescia, 25123 Brescia, Italy
Francesco Bertagna, Department of Surgical Specialties, Radiological and Forensic Sciences, Nuclear Medicine Section, University of Brescia, 25123 Brescia, Italy
Author contributions: All the Authors made substantial contributions to conception and design of the study, acquisition of data, or analysis and interpretation of data, drafted the article or made critical revisions related to important intellectual content of the manuscript, and finally approved the version of the article to be published. In particular, Baiocchi GL conceived the study and wrote the paper; Molfino S performed Literature search; Frittoli B, Pigozzi G, Gheza F, Gaverini G, Tarasconi A, Ricci C and Bertagna F analyzed the data provided by Molfino S; Grazioli L revised radiology-directed Literature; Tiberio GAM and Portolani N reviewed the paper.
Conflict-of-interest: No potential conflicts of interest relevant to this article were reported.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Gian Luca Baiocchi, Professor, Department of Medical and Surgical Sciences, Surgical Clinic, University of Brescia, III Chirurgia, Spedali Civili di Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy. gianluca.baiocchi@unibs.it
Telephone: +39-30-3995600 Fax: +39-30-3397476
Received: January 29, 2015
Peer-review started: January 29, 2015
First decision: March 10, 2015
Revised: April 12, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: June 21, 2015
Peer-review started: January 29, 2015
First decision: March 10, 2015
Revised: April 12, 2015
Accepted: May 7, 2015
Article in press: May 7, 2015
Published online: June 21, 2015
Core Tip
Core tip: This paper enter a clinical debate which has real relevance in the daily practice in the field of pancreatic cystic neoplasm, as a number of asymptomatic intraductal papillary mucinous tumors (IPMNs) are diagnosed every day by abdominal imaging, and the actual most common clinical attitude provides for a weak diagnostic pathway. However, in the light of an unanimous literature, this attitude would be a while dangerous, as up to 30%-40% of IPMN cases would develop a second malignancy in their life. The same should be underlined when discussing the follow-up protocols.