Published online Jun 21, 2015. doi: 10.3748/wjg.v21.i23.7120
Peer-review started: February 11, 2015
First decision: March 10, 2015
Revised: March 24, 2015
Accepted: April 28, 2015
Article in press: April 28, 2015
Published online: June 21, 2015
Core tip: The number of cases of refractory post-endoscopic submucosal dissection (ESD) strictures will increase as the indications for ESD expand. Dysphagia related to the stricture is primarily treated using repeated dilatation treatments, which risk complications and a diminished quality of life. Dysmotility and inflammation-associated disorders at the site may reflect the mechanisms of dysphasia. However, anti-scarring agent administration, endoscopic modalities, and regenerative medicine have limited effects. The development and subsequent long-term assessment of new technologies for the prevention and control of carcinogenesis will be required based on the limited accuracy of preoperative staging and the risk of local recurrence.