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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2015; 21(20): 6194-6205
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6194
Published online May 28, 2015. doi: 10.3748/wjg.v21.i20.6194
Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways
Guang-Ming Huang, Yu Sun, Xin Ge, Xin Wan, Chun-Bo Li, Department of General Surgery, Heilongjiang Provincial Hospital, Harbin 150036, Heilongjiang Province, China
Author contributions: Huang GM and Sun Y contributed equally to this work; Huang GM, Sun Y and Ge X designed the research; Huang GM, Wan X and Li CB performed the research; Sun Y analyzed the data; Huang GM, Sun Y and Ge X wrote the manuscript.
Ethics approval: The study was reviewed and approved by the Heilongjiang Provincial Hospital Institutional Review Board.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Ethics Committee of Heilongjiang Province’s Hospital (IACUC protocol number: 2008-010).
Conflict-of-interest: The authors have no conflict of interest to declare.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xin Ge, MD, Department of General Surgery, Heilongjiang Provincial Hospital, 82 Zhongshan Road, Harbin 150036, Heilongjiang Province, China. gexin628@163.com
Telephone: +86-451-87131193 Fax: +86-451-87131195
Received: September 28, 2014
Peer-review started: September 29, 2014
First decision: October 29, 2014
Revised: November 22, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: May 28, 2015
Peer-review started: September 29, 2014
First decision: October 29, 2014
Revised: November 22, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: May 28, 2015
Core Tip
Core tip: This study evaluated the effects of gambogic acid on colon cancer cells. Treatment of a human colon cancer cell line with gambogic acid inhibited proliferation via induction of apoptosis. Moreover, the growth of colon cancer cell xenograft tumors in mice was reduced by injections of gambogic acid. These anti-cancer effects were likely mediated through death receptor and mitochondrial pathways.