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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Insights into glycan biosynthesis in chemically-induced hepatocellular carcinoma in rats: A glycomic analysis
Amr Amin, Asma Bashir, Nazar Zaki, Diane McCarthy, Sanjida Ahmed, Mohamed Lotfy
Amr Amin, Asma Bashir, Mohamed Lotfy, Department of Biology, College of Science, UAE University, Al-Ain 15551, United Arab Emirates
Amr Amin, Zoology Department, Faculty of Science, Cairo University, Cairo 12613, Egypt
Nazar Zaki, Intelligent Systems, College of Information Technology, UAE University, Al-Ain 17551, United Arab Emirates
Diane McCarthy, Ezose Sciences Inc., Pine Brook, NJ 07058, United States
Sanjida Ahmed, Eastern Biotech and Life Sciences, Dubai 212671, United Arab Emirates
Mohamed Lotfy, Hormones Department, National Research Center, Cairo 12622, Egypt
Author contributions: Amin A designed the study, supervised the experimental work, interpreted the data and helped to write the manuscript; Bashir A helped in data interpretation, writing the manuscript and in the presentation of some figures; Bashir A performed the t-test statistical analysis; Zaki N helped with data interpretation; McCarthy D performed the glycomic experiment, helped in writing the manuscript and in the presentation of some figures; Lotfy M shared in the statistical analysis; all authors read and approved the final manuscript.
Supported by National Research Foundation Grant No. UIRCA 2012-21832 for A. Amin.
Ethics approval: The study was reviewed and approved by UAE University No.1185/10.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the UAE University (Ethics approval No.1185/10).
Conflict-of-interest: No potential conflicts of interest relevant to this article were reported.
Data sharing: Technical appendix, statistical code, and dataset available from the corresponding author at (a.amin@uaeu.ac.ae).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Amr Amin, PhD, Professor, Department of Biology, College of Science, UAE University, University Street, Al-Ain 15551, United Arab Emirates. a.amin@uaeu.ac.ae
Telephone: +97-13-7136519 Fax: +97-13-7134927
Received: November 26, 2014
Peer-review started: November 27, 2014
First decision: December 26, 2014
Revised: January 19, 2015
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: May 28, 2015
