Prospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 644-652
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.644
Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms
Ali S Alfazari, Bayan Al-Dabbagh, Wafa Al-Dhaheri, Mazen S Taha, Ahmad A Chebli, Eva M Fontagnier, Zaher Koutoubi, Jose Kochiyi, Sherif M Karam, Abdul-Kader Souid
Ali S Alfazari, Bayan Al-Dabbagh, Department of Medicine, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Bayan Al-Dabbagh, Department of Chemistry, College of Science, UAE University, PO Box 15551, Al Ain, United Arab Emirates
Wafa Al-Dhaheri, Sherif M Karam, Department of Anatomy, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Mazen S Taha, Ahmad A Chebli, Eva M Fontagnier, Zaher Koutoubi, Tawam Hospital, PO Box 15258, Al Ain, United Arab Emirates
Jose Kochiyi, Abdul-Kader Souid, Department of Pediatrics, United Arab Emirates University, PO Box 15258, Al Ain, United Arab Emirates
Author contributions: Alfazari AS, Karam SM and Souid AK designed the study, interpreted the data and drafted the manuscript; Al-Dabbagh B performed the biochemical analyses; Al-Dhaheri W performed the histological study; Kochiyi J performed the HPLC study; Taha MS, Chebli AA, Fontagnier EM and Koutoubi Z supplied the clinical samples; all authors read and approved the final manuscript.
Supported by Grants from United Arab Emirates University and National Research Foundation, No. UAEU-NRF 31M096.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sherif M Karam, Professor, Department of Anatomy, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates. skaram@uaeu.ac.ae
Telephone: +971-3-7137493 Fax: +971-3-7672033
Received: April 21, 2014
Peer-review started: April 21, 2014
First decision: May 29, 2014
Revised: June 30, 2014
Accepted: July 30, 2014
Article in press: July 30, 2014
Published online: January 14, 2015
Core Tip

Core tip: Using small gastric mucosal biopsies obtained from patients with upper gastrointestinal symptoms, several cellular bioenergetic and dynamic parameters were measured and correlated with the histopathological features of the gastric mucosa.