Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.453
Peer-review started: March 28, 2014
First decision: May 29, 2014
Revised: June 12, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 14, 2015
Core tip: A constant/high level of EphB and ephrin-B coexpression was identified as a feature common to experimentally induced gastric dysplasia and human gastric carcinoma cell lines, as compared to normal and regenerating gastric epithelia. Based on these, we proposed that the stable/robust EphB and ephrin-B coexpression is a marker of dysplastic/oncogenic transformation. Eph signaling in tumor cells likely has a suppressive role during tumor progression, with Eph and ephrin coexpressed on the same cell engaging in non-productive interactions via lateral inhibition and thereby silencing downstream signaling. These results can be useful for the early and accurate diagnosis of gastric tumors.