Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 14, 2015; 21(2): 439-452
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.439
Increased density of tolerogenic dendritic cells in the small bowel mucosa of celiac patients
Tamara Vorobjova, Oivi Uibo, Kaire Heilman, Raivo Uibo
Tamara Vorobjova, Raivo Uibo, Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, 51014 Tartu, Estonia
Oivi Uibo, Department of Pediatrics, University of Tartu, Tartu, Estonia, Children’s Clinic of Tartu University Hospital, 51014 Tartu, Estonia
Kaire Heilman, Department of Pediatrics, University of Tartu, Tartu, Estonia, Tallinn’s Children’s Hospital, 13419 Tallinn, Estonia
Author contributions: Vorobjova T and Uibo R contributed equally to the research design; Vorobjova T performed the research, including immunohistochemical and immunofluorescence studies and microscopy, and analyzed the data and wrote the paper; Uibo O and Heilman K were responsible for the collection of clinical material, performed the gastroduodenoscopy and revised and approved the final version of the article; Uibo R guided and supervised the research and the drafting and editing of the final revision of the article.
Supported by Grants from the Estonian Research Foundation, No. 7749 and No. 8334; EU Regional Developmental Fund; and the Estonian Ministry of Education and Research, No. SF 0180035s08 and No. IUT20-43.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Tamara Vorobjova, MD, PhD, Sc med, Senior Researcher, Department of Immunology, Institute of Biomedicine and Translational Medicine, University of Tartu, Ravila 19, 51014 Tartu, Estonia.
Telephone: +372-7-374233 Fax: +372-7-374232
Received: April 1, 2014
Peer-review started: April 2, 2014
First decision: April 28, 2014
Revised: May 15, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 14, 2015
Core Tip

Core tip: Significantly higher densities of CD11c+ dendritic cells (DCs) and of tolerogenic IDO+, CD103+ and Langerin+ DCs in the small bowel mucosa of patients with celiac disease (CD) compared with subjects with normal small bowel mucosa were revealed using immunohistochemistry in 74 patients. This article highlights the participation of diverse DC subsets in the pathological processes in the small bowel mucosa, pointing out the importance of Langerin+ DCs in untreated CD patients with and without type 1 diabetes and indicating the possible involvement of tolerogenic DCs in regulatory T cells development to maintain intestinal immunological tolerance in CD patients.