Published online May 7, 2015. doi: 10.3748/wjg.v21.i17.5138
Peer-review started: January 11, 2015
First decision: February 10, 2015
Revised: February 20, 2015
Accepted: March 31, 2015
Article in press: March 31, 2015
Published online: May 7, 2015
Core tip: Liver fibrosis, if untreated, progresses to cirrhosis and liver failure or malignancy. Liver fibrosis is reversible and potentially heritable process. Heritability and complete reversibility of liver fibrosis although debatable are of profound importance for research and therapy. Epigenetic mechanisms regulate both processes and hold the key for deciphering their regulatory mechanisms and providing new and much needed therapeutic options.