Copyright
©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 14, 2015; 21(10): 2926-2936
Published online Mar 14, 2015. doi: 10.3748/wjg.v21.i10.2926
Published online Mar 14, 2015. doi: 10.3748/wjg.v21.i10.2926
Anti-proliferation effects of Twist gene silencing in gastric cancer SGC7901 cells
Hui Zhang, Jian Gong, Di Kong, Hong-Yi Liu, Department of Oncology Surgery, Tianjin Nankai Hospital, Tianjin 300100, China
Author contributions: Zhang H and Liu HY defined the research theme; Liu HY designed the methods; Zhang H performed the majority of experiments; Gong J carried out the laboratory experiments; Kong D analyzed the data; Zhang H and Liu HY interpreted the results and wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Hong-Yi Liu, Department of Oncology Surgery, Tianjin Nankai Hospital, No. 122, Nankai Sanwei Road, Nankai District, Tianjin 300100, China. hongyiliu666@163.com
Telephone: +86-22-27435233 Fax: +86-22-27435239
Received: September 13, 2014
Peer-review started: September 13, 2014
First decision: October 14, 2014
Revised: October 22, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 14, 2015
Peer-review started: September 13, 2014
First decision: October 14, 2014
Revised: October 22, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 14, 2015
Core Tip
Core tip: Twist is a highly conserved transcription factor gene in gastric cancer. Silencing of the Twist gene could induce apoptosis of human gastric cancer SGC7901 cells, induce cell cycle arrest at the G0/G1 phase, inhibit cell proliferation, and reduce the ability of cell migration and invasion. The current research provides a potential gene therapy target for gastric cancer.