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World J Gastroenterol. Mar 7, 2014; 20(9): 2365-2373
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2365
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2365
Sweet food improves chronic stress-induced irritable bowel syndrome-like symptoms in rats
Sang-Gyun Rho, Department of Emergency Medical Services, Sunmoon University, Chungnam Asan 336-708, South Korea
Yong Sung Kim, Department of Gastroenterology and Wonkwang Digestive Disease Research Institute, Wonkwang University Sanbon Hospital, Gyeonggi Gunpo 435-040, South Korea
Suck Chei Choi, Department of Gastroenterology and Wonkwang Digestive Disease Research Institute, School of Medicine, Wonkwang University, Jeonbuk Iksan 570-974, South Korea
Moon Young Lee, Department of Physiology and Institute of Wonkwang Medical Science and Wonkwang Digestive Disease Research Institute, School of Medicine, Wonkwang University, Jeonbuk Iksan 570-749, South Korea
Author contributions: Rho SG and Lee MY performed the majority of experiments; Rho SG contributed to the acquisition and analysis of data, making the draft of the manuscript and to provide funding; Kim YS contributed to make the conception and design of the study, interpretation of data and revision of the manuscript; Choi SC participated in making the conception and design of the study and contributed to the interpretation of data; Lee MY contributed to the making of conception and design of the study, analysis and interpretation of data, revision of the manuscript, approval of the final version of the manuscript.
Supported by 2011 Sunmoon University in South Korea
Correspondence to: Moon Young Lee, MD, PhD, Department of Physiology and Institute of Wonkwang Medical Science and Wonkwang Digestive Disease Research Institute, School of Medicine, Wonkwang University, Shinyong-Dong 344-2, Iksan, Jeonbuk Iksan 570-749, South Korea. lmy6774@wku.ac.kr
Telephone: +82-63-8506774 Fax: +82-63-8526108
Received: October 30, 2013
Revised: December 6, 2013
Accepted: January 3, 2014
Published online: March 7, 2014
Revised: December 6, 2013
Accepted: January 3, 2014
Published online: March 7, 2014
Core Tip
Core tip: Stress has an important role in the pathogenesis of irritable bowel syndrome (IBS), and palatable foods have been used as an ameliorator for psychological stress. Several reports have supported the hypothesis that palatable foods are used for consolation from psychological stress. Thus we hypothesized that hypothalamic-pituitary-adrenal axis function and immune status in the plasma and colon could be altered by chronic stress, and these changes could be attenuated by concurrent ingestion of sweet food. These results imply that reducing the effect of stress appropriately by any means is important for preventing induces gastrointestinal symptoms in a patient with IBS.